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Friday, April 28, 2017

BACTERICIDAL VERSUS BACTERIOSTATIC - Bacteriostatic antibiotics inhibit reproduction and growth, while bactericidal antibiotics kill the bacteria. Antibiotics can also be distinguished as broad spectrum and narrow spectrum antibiotics. Antibiotics that are limited to treating specific infections are known as narrow spectrum while those that can treat a wide range of infections are called broad spectrum.

Bactericidal versus

Bacteriostatic

Antibiotics are generally divided into two groups based on their mode of action.

Bacteriostatic antibiotics inhibit reproduction and growth, while bactericidal antibiotics kill the bacteria.

Bactericidal versus bacteriostatic can be different in many aspects.

This article will highlight those differences as well as other distinction approaches of antibiotics, such as broad spectrum and narrow spectrum antibiotics.

Read on to know how to use the right antibiotics at the right time.

Bactericidal versus Bacteriostatic

1. Definition

Bactericidal Antibiotics: As the spelling shows, the suffix 'cidal' means kill; therefore, bactericidal antibiotics work by killing the bacteria. And their actions are irreversible.

There are different mechanisms in which bactericidal antibiotics kill bacteria. Here is an example:

Polymyxin B works by damaging the membrane of the bacteria, which results in all the contents pouring out. For bacteria to survive, ions have to be balanced on both sides of the plasma membrane because of osmosis.

This antibiotic disrupts the balance leading to the pouring out of the important molecules like RNA and DNA of the bacteria.

More bactericidal antibiotics can include vancomycin, metronidazole, aminoglycosides, fluoroquinolones, penicillin, cephalosporins, etc.

Bacteriostatic Antibiotics: As the suffix 'static' meaning stable, bacteriostatic antibiotics inhibit growth or reproduction of bacteria, whose action is reversible.

Bacteria divide at a very fast rate leading to their number escalating in a very short period.

However, if they are not dividing and growing, the human's immune system is able to fight and get rid of the bacteria.

An example of bacteriostatic antibiotics is tetracycline. It operates by inhibiting bacterial ribosome; as a result, new proteins cannot be formed.

The bacteria will not die since it already has enough protein to survive, but it will not divide with not sufficient proteins for division.

Sulfa drugs are also bacteriostatic. They work by preventing processes that bacteria need to make proteins, RNA and DNA. Without these 3 components, bacteria cannot divide.

More bacteriostatic antibiotics can include chloramphenicol, trimethoprim, clindamycin,sulfamethoxazole, erythromycin, etc.

2. Bactericidal versus Bacteriostatic Comparisons

Aside from the definition, bactericidal and bacteriostatic antibiotics have some other differences, including:

·  Bactericidal decrease the number of bacteria, while bacteriostatic antibiotics do not decrease instead they stagnate multiplication.

·  When bacteriostatic antibiotics are used, the bacteria are still viable. However, this is not the case for bactericidal.

·  Bacteriostatic antibiotics let the immune system fight infections while bactericidal do not.

·  High doses of bacteriostatic antibiotics can work as bactericidal, meanwhile, low doses of bactericidal antibiotics can work as bacteriostatic

·  Minimum inhibitory concentration (MIC) is the minimum bacteriostatic drugs concentration required to prevent growth of bacteria, while minimum bactericidal concentration (MBC) is the minimum bactericidal concentration required to kill bacteria.

Bactericidal versus Bacteriostatic—When to Apply

From the above comparison, it seems that bactericidal antibiotics are the better choice, which is believed for a long time being as a misconception.

The type of infection you have will determine which

type of antibiotic to use.

·  Bactericidal drugs treat diseases like meningitis and endocarditis. Noticeably, bactericidal actions can be antagonized by bacteriostatic antibiotics when treating meningitis.

·  For the function of preventing staphylococcal wound infections and treating UTIs (urinary tract infections), bacteriostatic antibiotics work as well as bactericidal antibiotics.

·  For infections that affect the central nervous system,bactericidal antibiotics can cause inflation as a side effect due to the releasing of bacterial products; therefore, it is advisable that bactericidal should be taken together with corticosteroids.

·  In cases of clostridial gangrene and streptococcal, some bacteriostatic drugs are ideal. This is because they prevent the production of toxins, which cause most of the morbidity.

Other Categories and Types of Antibiotics

1. Broad vs.Narrow Spectrum Antibiotics

Antibiotics can also be distinguished as broad spectrum and narrow spectrum antibiotics.

Antibiotics that are limited to treating specific infections are known as narrow spectrum while those that can treat a wide range of infections are called broad spectrum.

2. Other Types of Antibiotics

Antibiotics	How It Is Used
Penicillin	They are used for several types of infections like urinary tract infections, chest infections and skin infections.
Cephalosporins	They treat a wide range of infections as well as serious infections like meningitis and septicaemia (presence of disease-causing bacteria in the blood).
Aminoglycosides	They are mostly and merely used to treat serious conditions like septicaemia, due to their severe side effects like kidney damage and hearing loss. Also, they have to be injected or used as eye or ear drops, because they can easily broke down in the digestion system.
Tetracyclines	Used to treat a wide range of infections. It is mostly used to treat moderate to serious acne as well as rosacea that causes spots and skin flushing.
Macrolides	As a good substitute for penicillin, it is often used for patients who are allergic to penicillin or bacteria that is resistant to penicillin. Diseases like chest and lung infections can be cured by this medicine.
Fluoroquinolones	Broad spectrum antibiotics that treat a broad variety of infections.

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INFECTIOUS DISEASES AND WATER - Changing environments linked to such trends as intensified water resources development and urbanization, and the accompanying demographic changes, have created conditions where vector-borne diseases can gain new strongholds. International travel has contributed to the spread of pathogens to areas where the vector was already present but so far innocuous.

Water and

Infectious Diseases

EMERGING ISSUES OF WATER AND INFECTIOUS DISEASES

Water treatment issues of infectious disease starts primarily with the concerns of emerging pathogens.

What is an emerging pathogen?

Emerging pathogens are those that have appeared in a human population for the first time, or have occurred previously but are increasing in incidence or expanding into areas where they have not previously been reported, usually over the last 20 years (WHO, 1997).

Re-emerging pathogens are those whose incidence is increasing as a result of long-term changes in their underlying epidemiology (Woolhouse,2002).

By these criteria, 175 species of infectious agent from 96 different genera are classified as emerging pathogens. Of this group, 75% are zoonotic species.

Improved methods of surveillance, epidemiological studies and the continuous development of more advanced methods of diagnosis have allowed us to detect new pathogenic species of micro-organism or to associate a known micro-organism with a new or atypical set of disease symptoms.

Furthermore, the agents of several diseases that were thought to have been controlled are re-emerging as a result of adaptive changes in the pathogen, changes to the immunological status of the population normally affected.

Developments in our understanding of the relationships between water and human health have been characterized by the periodic recognition of previously unknown pathogens or of the water-related significance of recognized pathogens.

Several studies have confirmed that water-related diseases not only remain a leading cause of morbidity and mortality worldwide, but that the spectrum of disease is expanding and the incidence of many water-related microbial diseases is increasing.

Since 1970, several species of micro-organism from human and animal faeces and from environmental sources, including water, have been confirmed as pathogens.

Examples include Cryptosporidium, Legionella, Escherichia coli O157 (E. coli O157), rotavirus, hepatitis E virus and norovirus (formerly Norwalk virus).

Furthermore, the importance of water in the transmission of recognized pathogens is being continually assessed as new tools become available through advances in science, technology and epidemiology.

Helicobacter pylori (H. pylori) is an example of a recently emerged pathogen that may be transmitted through water.

Similarly, water-related vector-borne pathogens have been (re-) emerging over the past 20 years.

To a large extent this has been caused by the emergence and spread of drug-resistant parasites (for example, the Plasmodium species causing malaria).

There is a strong link between H. pylori infection and gastric cancer in many countries, but there are large inter-country variations in incidence of gastric cancer and H. pylori seroprevalence seen among many Asian countries.

For example, the prevalence of H. pylori infection is high in India and Bangladesh, but low gastric cancer rates have been reported.

Factors that may influence the etiology of gastric cancer include the genetic diversity of the infecting H. pylori strains and differences in the host genetic background in various ethnic groups.

These factors, in addition to environmental factors, such as personal hygiene and dietary habits, reflect the multifactorial etiology of gastric cancer (Miwa, Sakaki & Sugiyama, 2002).

A number of studies have demonstrated that H. pylori survives in water although isolation of H. pylori from water systems has been shown to be difficult.

Changing environments linked to such trends as intensified water resources development and urbanization, and the accompanying demographic changes, have created conditions where vector-borne diseases can gain new strongholds.

International travel has contributed to the spread of pathogens to areas where the vector was already present but so far innocuous (for example, West Nile virus in North America).

Major etiological agents of infectious diseases identified since 1972:

1972	Small round structured viruses Diarrhoea	1989	Hepatitis C virus Parenterally transmitted non-A, non-B hepatitis
1973	Rotaviruses Infantile diarrhoea	1990	Human herpesvirus-7 Exanthema subitum
1975	Astroviruses Diarrhoea	1990	Hepatitis E virus Enterically transmitted non-A, non-B hepatitis
1975	Parvovirus B19 Aplastic crisis in chronic haemolytic anaemia	1991	Hepatitis F virus Severe non-A, non-B hepatitis 1992 Vibrio cholerae O139:H7 New strain associated with epidemic cholera
1976	Cryptosporidium parvum Acute enterocolitis	1992	Bartonella henselae CAT-scratch disease, bacillary angiomatosis
1977	Ebola virus Ebola haemorrhagic fever	1993	Sin nombre virus Hantavirus pulmonary syndrome
1977	Legionella pneumophila Legionnaires' disease	1993	Hepatitis G virus Non A-C hepatitis
1977	Hantaan virus Haemorrhagic fever with renal syndrome	1994	Sabia virus Brazilian haemorrhagic fever
1977	Campylobacter spp. Diarrhoea	1994	Human herpesvirus-8 Kaposi's sarcoma
1980	Human T-cell lymphotropic virus-1(HTLV-1) Adult T-cell leukaemia/ HTLV-1 associated myelopathy	1995	Hendravirus Castleman's disease
1982	HTLV-2 Hairy T-cell leukaemia	1996	Prion (BSE) Meningitis, encephalitis
1982	Borrelia burgdorferi Lyme disease	1997	Influenza A virus New variant Creutzfeldt-Jakob disease
1983	HIV-1, HIV-2 Acquired immunodeficiency syndrome	1997	Transfusion-transmitted virus 1997 Enterovirus 71 Epidemic encephalitis
1983	Escherichia coli O157:H7 Haemorrhagic colitis; haemolytic uremic syndrome	1998	Nipah virus Meningitis, encephalitis
1983	Helicobacter pylori Gastritis, gastric ulcers, increased risk of gastric cancer 1988 Human herpesvirus-6 Exanthema subitum	1999	Influenza A virus Influenza (Hong Kong)
1989	Ehrlichia spp. Human ehrlichiosis	1999	West Nile-like virus Encephalitis (New York) (Desselberg, 2000)

An outbreak of arboviral encephalitis was first recognized in New York City in 1999.

The cause of the outbreak was confirmed as a West Nile-like virus. Before and concurrent with this outbreak, local health officials observed increased fatalities among New York City birds, especially crows.

Tissue specimens from these birds with pathologic evidence of encephalitis were reported as positive for West Nile-like virus sequence by genomic analysis, implying these as the vectors.

Four human deaths occurred among elderly persons. One case-patient with onset in late August reported a history of travel to Africa completed in June 1999.

Vector control measures were initiated to control the host-seeking adult Culex pipiens mosquito population (MMWR, 1999).

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