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Copper Poisoning
Are you
COPPER poisoned? This trace mineral, often used in water pipes, becomes TOXIC
at very low exposures
By
Russel Davis
Copper is without a doubt one of the most
useful metals.
However, like any other metal, copper
exposure may lead to toxicity.
In turn, this toxicity may usher in the onset
of various diseases.
A large number of research and literature
have identified four of the most common causes of copper poisoning, including:
Environmental copper toxicity — Exposure to
various environmental sources of copper may increase the risk of copper
poisoning.
These sources include copper water pipes,
dental fillings, copper-contaminated water and foods and various cookware and
jewelries.
Other sources include copper intrauterine
devices, copper fungicides and other toxic metals.
Oxidative stress — Higher levels of
oxidative stress were found to result in reduced expression of cellular
antioxidants — such as metallothionein and glutathione — that are known to bind
together to free copper ions
Genetic mutations — Genetic mutations
that modify copper-transport proteins were found to cause copper toxicity.
Another cause of copper poisoning are genetic
mutations that lead to the development of both Huntington’s disease and
Wilson’s disease.
Nutrient deficiencies — Copper toxicity
was also found to be triggered by vegetarian and vegan diets.
Signs and symptoms of copper poisoning
Copper poisoning exhibits some of the most
alarming symptoms. According to MedLinePlus, ingesting large amounts of copper
may trigger the following symptoms:
Abdominal pain
Vomiting
Diarrhea
Jaundice or yellow skin
Exposure to the toxic chemical through
inhalation of dust and fumes may lead to the onset of acute syndrome of metal
fume fever. People suffering from the condition show these symptoms:
Fever
Chills
Cough
Headache
Chest pain
General weakness
Metallic taste in the mouth
On the other hand, long-term exposure to
copper may result in lung inflammation and permanent scarring, which in turn
may lead to reduced lung function. Symptoms may include the following:
Chills
Fever
Nausea
Shock
Pain
Vomiting
Weakness
Convulsions
Muscle aches
Burning sensation
Yellow eyes and yellow skin
Liver failure, kidney failure
Metallic taste in the mouth
Anemia or low red blood cell count
Diarrhea that may either be bloody or blue in
color
Diseases associated with copper toxicity
Copper poisoning is associated with a host of
adverse neurological inflammatory conditions.
In fact, researchers at the Proceedings of
the National Academy of Sciences found that copper toxicity leads to a
degeneration of the blood brain barrier in animal models.
Previous studies have noted that blood brain
barriers act as a primary defense mechanism that prevent toxic chemicals from
entering the brain.
These findings demonstrate that copper
accumulation over time may lead to the impairment of systems that remove
amyloid beta from the brain, a researcher said.
The scientific community has also long
established that copper toxicity may play a role in the onset of cancer.
In the 1930s, medical pioneer Dr. Emanuel
Revici found that cancer patients exhibited unusually high levels of copper.
Scientists noted that deranged copper
metabolism was seen in various types of cancer including breast, brain, ovarian
and bladder as well as gastric, lung, prostate and colon cancer.
However, a 2013 study revealed that
copper-depletion drug Tetrathiomolybdate was associated with marked reductions
in breast cancer recurrence in women with high relapse risk.
The findings were published in the Annals of
Oncology, the flagship publication of the European Society for Medical
Oncology.
Copper toxicity is likewise associated with
Huntington’s disease, a genetic condition marked by chorea or involuntary
muscular jerks.
A 2013 study conducted by researchers at the
Johns Hopkins University School of Medicine revealed that the disease was
characterized by significant increases in copper protein activities.
However, the researchers noted that copper
depletion treatment dramatically decreases gene expression in Huntington’s
disease.
Copper poisoning is also linked to other
diseases including Parkinson’s disease, Wilson’s disease and pyroluria, as well
as candida ablicans, obsessive compulsive disorder and schizophrenia.
Chemicals.News is a fact-based
public education website published by Chemicals News Features, LLC.
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